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Retin-A (Tretinoin) is a topical form of vitamin A. It reduces the formation of pimples and promotes quick healing of pimples that do develop, especially in the case of blackheads, pimples and papules.

Uses Tretinoin is used in the treatment of acne. How to take Use Tretinoin exactly as directed by your doctor. Wash your hands before and after applying this medication. Tretinoin is usually applied once daily at bedtime. Clean and pat dry the area of skin where you will apply Tretinoin. Applying Tretinoin to wet skin may cause skin irritation. Do not wash the treated area for at least one hour after applying Tretinoin. Avoid the use of any topical products on the treated area for at least one hour following application of this medication. Do not apply Tretinoin to eyes, ears, nostrils, mouth, angles of your nose, mucous membranes, open sores, or irritated skin. If you get medication in any of these areas, rinse it off with water. Application of an excessive amount of the Tretinoin cream may result in "pilling" of the medication. This does not reduce the effectiveness of the medication, but if pilling occurs, you should use less medication with the next application. Tretinoin should be used as part of a comprehensive skin care and sunlight avoidance program that includes the use of effective sunscreens (minimum SPF of 15) and protective clothing. Do not stop using Tretinoin if you do not see improvement in your condition immediately. Treatment with Tretinoin may be necessary for weeks or months before improvement is seen. If you are using Tretinoin to treat acne, a temporary worsening of acne may occur at the start of therapy. Side effects Serious side effects are not likely to occur. Stop using Tretinoin and seek emergency medical attention if you experience an allergic reaction (shortness of breath; closing of your throat; swelling of your lips, face, or tongue; or hives). You may experience some burning, warmth, stinging, tingling, itching, redness, swelling, dryness, peeling, or irritation while you are using Tretinoin. If these side effects are excessive, talk to your doctor. You may need a lower dose or less frequent applications of Tretinoin. If you notice a change in your skin color, contact your doctor. Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. Due to the possibility of irritation, it is advisable to begin treatment on a small area of skin. Exposure to the sun or to ultraviolet rays causes additional irritation. During treatment, such exposure should be avoided as much as possible or a sun block should be used. During the first weeks of treatment there may be an apparent worsening of the problem. Such a reaction is perfectly normal because small cysts deep within the skin are being eliminated at an accelerated rate. Tretinoin can increase sensitivity to wind and cold. Avoid prolonged exposure to the sun and sunlamps. Wear protective clothing and use an effective sunscreen. If any ingredient should cause hypersensitivity, discontinue use. Applying Tretinoin excessively will not produce faster or better results, and marked redness, peeling, or discomfort could occur. Over dosage with other retinoid has been associated with transient headache, facial flushing, celosias, abdominal pain, dizziness and ataxia. Precaution Do not use Tretinoin on skin that is sunburned, windburned, dry, chapped, or irritated. Also avoid using this medication in wounds or on areas of eczema. Wait until these conditions have healed before using Tretinoin. It is not known whether Tretinoin will harm an unborn baby. It is recommended that the use of Tretinoin be avoided during pregnancy. Do not use Tretinoin without first talking to your doctor if you are pregnant or thinking about becoming pregnant. Tretinoin passes into breast milk. Do not use Tretinoin without first talking to your doctor if you are breast-feeding a baby. If you have been previously treated with keratolytic preparations or exfoliants, you should wait until any skin rash clears up before beginning even low strength treatment. Studies of the effect of this product on pregnant women are incomplete. For this reason, it should only be applied when absolutely necessary and always under a doctor's supervision. The effectiveness of Tretinoin is almost always accompanied by skin irritation. In the treatment of acne, this phenomenon is directly related to the effectiveness of the product and disappears once applications are more spaced out. Cosmetics may be used, but clean skin thoroughly before applying Tretinoin. Drug interactions Do not use Tretinoin without first talking to your doctor if you are taking any of the following medicines: a thiazide diuretic such as hydrochlorothiazide (HCTZ, HydroDiuril, Esidrix, Microzide, Oretic), chlorothiazide (Diuril), chlorthalidone (Hygroton, Thalitone), indapamide (Lozol), metolazone (Mykrox, Zaroxolyn), and others; a tetracycline antibiotic such as tetracycline (Sumycin, Panmycin, Robitet, others), minocycline (Dynacin, Minocin, Vectrin), doxycycline (Doryx, Monodox, Vibramycin, Vibra-Tabs), demeclocycline (Declomycin), and others; a fluoroquinolone antibiotic such as lomefloxacin (Maxaquin), sparfloxacin (Zagam), ciprofloxacin (Cipro), ofloxacin (Floxin), and others; a sulfonamide antibiotic such as sulfamethoxazole (Gantanol), sulfisoxazole (Gantrisin), sulfamethoxazole-trimethoprim (Bactrim, Septra, Cotrim), and others; or a phenothiazine such as chlorpromazine (Thorazine), prochlorperazine (Compazine), fluphenazine (Permitil, Prolixin), promethazine (Phenergan, Promethegan), perphenazine (Trilafon), and others. The medications listed above may increase the sensitivity of your skin to UV rays from sunlight or artificial light (e.g., sunlamps). Generally, Tretinoin should not be used with any of the medicines listed above. Do not use products containing benzoyl peroxide, sulfur, resorcinol, or salicylic acid during treatment with Tretinoin unless otherwise directed by your doctor. The combination could lead to severe skin irritation. Avoid as much as possible products that can increase skin irritation such as other skin medicines (unless prescribed by your doctor); medicated or abrasive (rough) soaps or skin cleansers; permanent wave solutions; chemical hair removers or waxes; electrolysis; products with alcohol, spices, astringents, or lime; cleansers, shampoos, or cosmetics with a strong drying effect; or other products that may irritate your skin. Missed dose Apply the missed dose as soon as you remember. Do not apply a double dose of Tretinoin. Storage Store Tretinoin cream at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store in a tightly closed container. Store away from heat and light. Do not store in the bathroom. Keep Tretinoin cream out of the reach of children and away from pets.

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