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Provera (medroxyprogesterone) is a female hormone. It is used to treat amenorrhea (lack of menstrual flow), abnormal bleeding from the uterus, or endometriosis. It is also used to treat certain types of cancer, and menopausal symptoms as part of combination hormone replacement therapy (estrogen and progestin HRT).

Uses Medroxyprogesterone is a female hormone. It is used to treat amenorrhea (lack of menstrual flow), abnormal bleeding from the uterus, or endometriosis. It is also used to treat certain types of cancer, and menopausal symptoms as part of combination hormone replacement therapy (estrogen and progestin HRT). Progestins such as medroxyprogesterone lower the risk of estrogen-related cancer of the uterus during HRT therapy. Combination HRT should not be used to prevent heart disease. How to take May be taken with food or immediately after a meal to prevent stomach upset. Take this medication as prescribed. It is usually taken for 5 to 13 days during the later end of the menstrual cycle. A menstrual period should begin within 3 to 10 days of stopping the medication. For treatment of cancer, the medication is usually taken more often. Follow the dosing schedule carefully. Consult your doctor or pharmacist if you have any questions. Side effects More common side effects may include: Acne, anaphylaxis (life-threatening allergic reaction), blood clot in a vein, lungs, or brain, breakthrough bleeding (between menstrual periods), breast tenderness or sudden or excessive flow of milk, cervical erosion or changes in secretions, depression, excessive growth of hair, fever, fluid retention, hair loss, headache, hives, insomnia, itching, lack of menstruation, menstrual flow changes, spotting, nausea, rash, skin discoloration, sleepiness, weight gain or loss, yellowed eyes and skin Precaution Before you take this medication, tell your doctor your medical history (and family history), including: high blood pressure, seizures, migraine headaches, diabetes, asthma, heart disease or blood vessel problems (e.g., stroke, heart attack), liver or kidney disease, blood clots, history of cancer, high blood level of cholesterol or fats, depression, excessive weight gain or fluid retention during menstrual cycle, jaundice (yellowing of skin or eyes). Because this drug can interfere with laboratory tests, tell the doctor and laboratory personnel that you take medroxyprogesterone. Due to the risk of fetal harm, this medication must not be used during pregnancy (especially during the first four months of pregnancy). If you become pregnant or think you may be pregnant, inform your doctor immediately. This drug passes into breast milk. However, there have been no reports (to date) of problems in nursing infants, breast-feeding while using very high doses of this medication is not recommended. Consult your doctor before breast-feeding. Drug interactions If medroxyprogesterone is taken with certain other drugs, the effects of either may be increased, decreased, or altered. It is especially important to check with your doctor before combining medroxyprogesterone with aminoglutethimide (Cytadren). Missed dose If you miss a dose, take as soon as remembered; do not take if it is almost time for the next dose, instead, skip the missed dose and resume your usual dosing schedule. Do not "double-up" the dose to catch up. Storage Store at room temperature between 59 and 86 degrees F (between 15 and 30 degrees C) away from moisture and sunlight. Do not store in the bathroom. Keep away from children and pets.

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